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KMID : 0370219880320010062
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Yakhak Hoeji
1988 Volume.32 No. 1 p.62 ~ p.69
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Effect of Ginseng on Na^(＋), K^(＋), -ATPase Activities of Potassium Deficient Rat Intestinal Mucosa
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Abstract
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We have studied the effect of fasting on Na+, K+-ATPase activities in the rat intestinal mucosa. Rats were fasted for 18,-´48hr. Intestinal microsomal fraction was prepared by the method of Robinson and ATPase activities were determined by the modified method of Fiske and Subbarow. Na+, K+-ATPase activity was not changed after fasting for 18 and 24 hr but significantly decreased after fasting for 48 hr. Fasting over 18 to 48 hr period had no effect on the Mg*-ATPase. Thus, it may be concluded that 48 hr fasting has inhibitory effect on rat intestinal absorptive capabilities. In order to study the effect of Ginseng on the Na+,K+-ATPase activities of the small intestine in chronic K+-depleted rats, rats were fed K+-depleted diets for 3 weeks and Ginseng ethanol extracts were administered orally for 3 weeks concomitantly.
ATPase activity was measured by the same method as fasting group. Na+, K+-ATPase activity in the K+-depleted diet group was increased and Ginseng ethanol extracts inhibited the increase of enzyme activity induced by K+-depleted diet. Thus, it may be suggested that increase in the intestinal Na+, K+-ATPase activity of chronic K+-depleted group may be due to the compensatory mechanism and administration of Ginseng with K+-depleted diet may be associated with inhibition of increase in the enzyme activity of the K+-depleted group due to the prevention of the K+ loss in the K+-depletion.
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